Vorapaxar sulfate( —— )

Catalog No. M17571 CAS No. 705260-08-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

Vorapaxar sulfate
Note

Research use only, not for human use.
Brief Description

Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.
Description

Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.(In Vitro):Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM.
In Vitro

Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

PAR-1
Research Area

——
Indication

——

CAS Number

705260-08-8
Formula Weight

590.66
Molecular Formula

C29H35FN2O8S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (211.63 mM)
SMILES

S(=O)(=O)(O)O.Fc1cc(c2cnc(/C=C/[C@@H]3[C@H]4[C@@H](C[C@H]5[C@H]3CC[C@@H](NC(=O)OCC)C5)C(=O)O[C@@H]4C)cc2)ccc1
Chemical Name

——

1. Chackalamannil S, et al. J Med Chem, 2008, 51(11), 3061-3064.

Calculator

molnova catalog